Psilocybin contraindications

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Some magic mushrooms to be degustated

Some contraindications that may affect you

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Psilocybin mushrooms are a source of hope for many people. Research demonstrates considerable results on patients with depression and severe anxiety.

What’s more, psilocybin isn’t considered a dangerous or addictive substance. However, it’s still important to be vigilant when it comes to potential side effects.

Avoid taking unnecessary risks

Psilocybin shouldn’t be taken lightly. We expect participants at Tangerine Retreat to be careful and understand what’s at stake.

There are several known contraindications to taking psilocybin, and Tangerine Retreat asks every person who enquires to undertake a questionnaire to assess the risk of any side effects linked to these contraindications.

This process enables us to help people who are potentially susceptible to side effects to avoid taking unnecessary risks.

Pregnant women and heart conditions

Taking magic truffles leads to a powerful psychedelic experience. It is therefore not recommended for pregnant women and people undergoing treatment for heart deficiencies, high blood pressure, or glaucoma to take any kind of psychoactive substance.

While the use of psilocybin may not pose a particular risk in and of itself, the emotions experienced throughout the psychological journey can have potentially dangerous side effects for vulnerable people (tachycardia, dizziness).

Risk of drug interaction

Interaction with drugs

Other than the contraindications linked to the use of psilocybin, the medical community also recognizes a risk linked to taking several other psychoactive (legal or illegal) substances at the same time. Combining psilocybin and cannabis, opioids, LCD, ayahuasca, or certain neuroleptics is therefore totally unpredictable and even dangerous.

Taking psychoactive substances risks altering brain chemistry more permanently.

Psilocybin and serotonin

Some treatments for depression (whether natural or chemical), are not recommended for people who want to use psilocybin. Selective serotonin reuptake inhibitors, monoamine-oxidase inhibitors, hypericum, and lithium all act directly on a natural neurotransmitter called serotonin.

Serotonin is directly involved in how we manage our emotions and our decision-making process, so it is also closely linked to our mood.

Taking psilocybin while on antidepressants

Certain classes of antidepressants affect the amount of serotonin available in the brain, in much the same way as psilocybin truffle does. Psilocin (the molecule that our body derives from psilocybin) and this type of medication have dangerously similar effects, making it essential to be careful to avoid taking both.

In some people, taking psychedelic truffles or mushrooms and antidepressants can lead to a serotonin overdose and, in turn, physiological over stimulation.

In some rare cases, simultaneously taking psychedelic mushrooms and selective serotonin reuptake inhibitors or monoamine-oxidase inhibitors can lead to serotonin syndrome. This is an infrequent but very serious side effect. In cases of serotonin syndrome, the overabundance of serotonin in the body can cause irreversible lesions to the brain or lead to death.

Should I stop my antidepressants?

We encourage all participants who are being treated for depression to be extremely careful. Consulting a doctor is the only way to understand and measure the risks related to any therapeutic treatment.

Some healthcare professionals can help their patients transition towards a temporary pause in their treatment, or, on the contrary, may firmly discourage it. Stopping any treatment for depression should be done gradually and under medical supervision.

We therefore strongly recommend that you first and foremost have a conversation with your doctor, who can assess the benefits (or not) of a psychedelic retreat for you.

Psychiatric contraindications to taking psilocybin

Researchers in psychiatry encourage patients suffering from psychiatric disorders to be careful when considering taking any psychedelic substance. Psilocybin is therefore not recommended for patients who:

  • Have been diagnosed with bipolar disorder, obsessive compulsive disorder, dissociative identity disorder, multiple personality disorder, borderline personality disorder, schizophrenia.
  • Are at hereditary risk of suffering from one of these disorders.

Because of the chemical shift in your brain that psilocin provokes, people suffering from a psychiatric disorder are more likely to experience problems and have a negative mystical experience. In these cases, doctors warn about the dangers of bringing on more long-term disorders such as depersonalization, and manic or psychotic behaviour.

These are also the same reasons that simultaneously taking neuroleptics and psilocybin is not recommended.

The main risk related to psilocybin

While side effects are possible but unlikely, the main risk associated with taking psilocybin comes from not understanding the product correctly.

Avoiding poisoning

Some poisonous mushrooms look very similar to those with psilocybin. It is therefore essential to ask the right people to select the right specimen for you.

Choose guidance

One of the overarching contraindications to taking any psychedelic truffle is improper preparation. The mystical journey that you go on and the emotions that are brought up require professional and well-meaning oversight.

Surrounding yourself with trustworthy people in a relaxing environment is a fundamental prerequisite to enjoying the best experience possible. Our process is not about giving people psilocybin, it’s about providing our participants with a whole mental ecosystem that allows them to achieve the maximum benefit from their personal quest with truffles.

All the scientific research on psilocybin even mentions the importance of guidance in guaranteeing a safe and beneficial journey.

A place of peace in the heart of the Netherlands

Psychedelic Retreat in the Netherlands

September 23-25, 2024

Spoken language(s) : Spoken language(s) french Spoken language(s) english Spoken language(s) german

  • Ceremony: one opportunity to take psilocybin
  • Protocol: one video session before and one after the retreat
  • Retreat: three days – two nights on site
  • From € 1,790

What research is being done into psilocybin?

Recognized institutions

For 40 years, researchers have been interested in the links between mental health and depression. These last 15 years have seen some specialized institutions shake up the common preconceptions around psilocybin, despite restrictions that remain in place in many countries. For example, we can cite the work of Imperial College London, Johns Hopkins Center for Psychedelic and Consciousness Research, and the Medical Council of Research in the UK.


Some researchers have observed positive effects in using psilocybin as a treatment for severe depression, alongside psychotherapy. Just one dose of psilocybin helped some patients achieve an improved state of mind.

Anxiety disorders

Other experiments are ongoing to try to establish a link between taking psychedelic mushrooms and reducing symptoms of anxiety. One study shows that occasional psilocybin use helps terminal cancer patients reduce their anxiety around death.

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